Functional protein levels are controlled at the transcriptional level as well as at the post-translational level though protein inactivation (de/phosphorylation), targeting or turnover. In other organisms, components regulating these processes have been identified. We are currently using yeast mutants deficient in regulating endogenous amino acid permeases (i.e. inactivation, targeting and degradation) to identify mechanisms involved in turnover and regulation of the plant permeases and to isolate the corresponding genes from plants. Furthermore we investigate the role of several novel transporters with unknown function.

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